Evidence Suggesting the Regulation of Coagulation Factor Levels in Rabbits by a Transferable Plasma Agent

New Zealand white rabbits were given 30 ml of goat serum intravenously. This procedure resulted in an immediate decrease in platelet count, fibrinogen, and levels of coagulation factors II, V, VII, and x, due to consumption coagulopathy. These factors returned toward baseline levels approximately 1 2 hr after the injection. Plasma from rabbits who had received goat serum 48 hr previously ( donor rabbits) was injected into recipient rabbits. This procedure resulted in a slight rise in the level of coagulation factor II ( range, 20%-30%) and a significant rise in factors V (35%-75%), VII (35%-235%), and X ( 35%-75%) in the recipients. When plasma from control donor rabbits who had not received goat serum was injected into recipients, there was no change in these coagulation factors. It is postulated that the reduction in coagulation factor levels in donor rabbits induces a “coagulopoietin” for each factor or one “coagulopoietin” for all factors which stimulates increased synthesis and/or release of these factors in recipient rabbits.